|
KMID : 0603520000050010015
|
|
Journal of Korean Association of Cancer Prevention
2000 Volume.5 No. 1 p.15 ~ p.23
|
|
|
Effects of Nucleic Acids Comples of Tuna Testis on Immunological Activities
|
|
Park Sang-Eun
Kim Ha-Won
Lee Seung-Ryong
Kim Byong-Kak
|
|
|
Abstract
|
|
|
|
Tuna is one of the most abundant fish caught in Korea. The uncleic acids complex, DW-DNA, is produced in large amount from the testis. In this study, the effects of DW-DNA on humoral and cellular immune responses were examined. When administered orally in ICR mice, DW-DNA increased the number of peritoneal exudate cells twice of that of the control. The ratio of polymorphonuclear cells infiltrated into the peritoneal cavity increased from 2% to 40% by the oral administration of DW-DNA. Flow cytometry analysis showed that the cell numbers of macrophage and cytotoxic T lymphocyte of the mouse spleen increased in the S180-bearing mice group in the early stage of tumor growth. In the later stage, while the immune cells decreased in the control group, DW-DNA treated group restored the decreased immune cells to their normal level inth tumor-bearing group. In the nonspecific immune response of the mice, the acid phosphatase production and superoxide anion secretion by the activated macrophages in the DW-DNA given group increased by 1.6-fold and 1.3-fold, respectively, as compared with those of the tumor control group. These results indicate that the DW-DNA treated group restored the decreased immune response of the tumor-bearing mice to the normal level. Therefore it is concluded that DW-DNA may act as an immunomodulator.
|
|
|
KEYWORD
|
|
|
Nucleotides, Immune response, B lymphocyte, Acid phosphatase, Superoxide anion, Macrophage
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|
|